Most people I talk with about determinism respond unfavorably. Their reactions seem to have more to do with their fears about the proliferation of the perspective (e.g., a fear of perpetuating nihilism) than their disagreement with its accuracy.

However, I do not see nihilism or destructive behaviors as the only reactions to adoption of this worldview. In fact, my own experience has been that it is far more helpful than harmful. In particular, I find the concept of determinism to be a highly effective key to unlocking compassion, both for others and for our selves.